European researchers ?conducted a study with mice models to uncover the pathway by which oral bacteria in the bloodstream affect endothelial progenitors. Endothelial progenitors are cells that can turn into endothelial cells, which make up the walls of blood vessels.?
The pathogen Porphyromonas gingivalis was found to ?corresponded with a significant movement of endothelial progenitors from the bone marrow?where the cells are created?to the blood stream.?
This allows the body to regenerate the endothelial cells when in the presence of harmful pathogens. However, the authors note that, ??Impaired endothelial regeneration after endothelial cell damage?as known to be elicited by periodontal pathogens?is closely connected to the development of atherosclerotic lesions.??
This led the authors to surmise, ?P. gingivalis is able to impair the body?s response to infection.?