Injectable Anesthetics
Injectable Anesthetics CATEGORY DESCRIPTION
Injectable local anesthetics interrupt the transmission of nerve impulses between the pain source and the brain by blocking the operation of the sodium potential. Amide injectable local anesthetics for dental use include lidocaine, mepivacaine, articaine, prilocaine and bupivacaine, which differ in terms of rate of onset, duration of action, and maximum recommended dosage. The more closely an anesthetic’s equilibrium pH approximates physiologic pH, the more rapid the onset of action will be, with more acidic solutions demonstrating a slower onset of action. Furthermore, the better the anesthetic molecule binds to the protein in the nerve’s sodium channel, the longer the duration of anesthesia will be.
Because local anesthetics are vasodilators that are absorbed into the circulation, they have systemic effects that are related directly to their blood plasma level. For this reason, local anesthetic cartridges contain a vasopressor in addition to the anesthetic agent. Vasoconstrictors (epinephrine and levonordefrin) counteract the vasodilatory action, slowing removal of the anesthetic from the area of the nerve and, therefore, prolonging its action. Also added is sodium chloride to make the anesthetic solution isotonic with the body tissues.
Patterson® Lidocaine Anesthetic HCL 2% with Epinephrine - 1.7 ml Cartridges, 50/:Box - 1:100,000
Patterson Dental
Patterson® Mepivacaine 2% HCl and 1:20,000 Levonordefrin Injection- Latex-Free Cartridge, 50/:Box
Patterson Dental
