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A composite that’s antibacterial, antibiofilm? Could be soon…..

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Imidazolium. Say that three times fast.

It’s the antibacterial agent that Penn Dental Medicine researchers embedded into their experimental composite resin in efforts to develop a plaque-resistant restorative material.

In a new study, an imidazolium-containing resin was evaluated and found to have very effective antibacterial properties and biofilm resistance. And there was a bonus. Because only a low dose of the antibacterial agent was needed, it only killed the microbes that came in contact, leaving surrounding tissue unaffected.

According to Geelsu Hwang, research assistant professor, “Dental biomaterials such as these need to achieve two goals: first, they should kill pathogenic microbes effectively, and, second, they need to withstand severe mechanical stress, as happens when we bite and chew. Many products need large amounts of anti-microbial agents to maximize killing efficacy, which can weaken the mechanical properties and be toxic to tissues, but we showed that this material has outstanding mechanical properties and long-lasting antibiofilm activities without cytotoxicity.”

Study results were published in a recent issue of ACS Applied Mateirals and Interfaces, and—GEEK ALERT—you can read the abstract.


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