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RE-GEN™ Bioactive Endo Sealer is a hydraulic, ready-to-use injectable bioactive paste that utilizes moisture naturally present in dentinal tubules to initiate a setting reaction. Endodontic sealers are used in the obturation of root canal systems to achieve a fluid-tight seal throughout the canal including the apical foramen, canal irregularities, and minor discrepancies between the dentinal wall of the root canal and the core filling material.